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We're Getting Mutants in the MCU - The Loop
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Definition:
- UPR orchestrates increased expression of key ERAD components
- in metazoans, different arms of the UPR up-regulate distinct sets of ERAD components (Yoshida et al., 2003; Dev Cell; Bernasconi et al., 2008; JBC) --> cells can dynamically alter the specificity of ERAD, not just its overall activity
