12 results

• ERAD substrates

  300px Definition:

  https://erad.fandom.com/wiki/ERAD_substrates

• Wiki Content

  1184;mso-padding-alt:0in 5.4pt 0in 5.4pt;mso-border-insideh:none;mso-border-insidev: none"

  https://erad.fandom.com/wiki/Wiki_Content

• E3 ubiquitin ligase

  300px Function:

  https://erad.fandom.com/wiki/E3_ubiquitin_ligase

• HRD3 / SEL1L

  300px Function: adaptor of E3 ubiquitin ligase complex HRD1 in ER membrane, HRD3 in yeast, SEL1L in metazoans; recruits misfolded proteins to E3 ligase and also recruits other adaptors, such as lectins Yos9p/OS-9

  https://erad.fandom.com/wiki/HRD3_/_SEL1L

• HRD1

  300px Function:

  https://erad.fandom.com/wiki/HRD1

• Doa10 (Doa10p)

  300px E3 ubiquitin ligase complex for substrates with misfolded cytosolic domains only other ERAD-active E3 in yeast besides Hrd1p, Has broad substrate specificity, encompassing membrane proteins, as well as soluble cytosolic and nuclear proteins

  https://erad.fandom.com/wiki/Doa10_(Doa10p)

• ERAD Wiki

  ERAD Write a description about your topic. Let your readers know what your topic is about and add some general information about it.

  https://erad.fandom.com/wiki/ERAD_Wiki

• HMG-CoA reductase (Hmg2p)

  300px yeast HMG-CoA reductase (Hmg2p) is the rate limiting enzyme in cholesterol synthesis example of physiological regulation of protein abundance via ERAD, when cholesterol levels are high, Hmg2p undergoes a lipid-induced structural change

  https://erad.fandom.com/wiki/HMG-CoA_reductase_(Hmg2p)

• Derlin (Der1p, DER1)

  300px Function: members of E3 complexes, yeast Der1p: multi-pass transmembrane protein that interacts with Hrd1p and Hrd3p as well as with substrates, dispensable for degradation of many substrates, contain a motif shared with rhomboid

  https://erad.fandom.com/wiki/Derlin_(Der1p,_DER1)

• Htm1 (Htm1p)

  300px Htm1p forms a disulfide-stabilized complex with Pdi1p which is necessary for both maximal Htm1p activity as well as its stability (Gauss et al., 2011; Mol Cell; Sakoh-Nakatogawa et al., 2009; JBC)

  https://erad.fandom.com/wiki/Htm1_(Htm1p)

• ERdj5

  300px interacts with EDEM1 and BiP, can reduce disulfide bonds of aberrantly linked proteins, accelerates ERAD when overexpressed (Ushioda et al., 2008; Science), substrate-binding J domain and disulfide-reactive thioredoxin domain are both critical

  https://erad.fandom.com/wiki/ERdj5

• UPR (unfolded protein response)

  300px Definition:

  https://erad.fandom.com/wiki/UPR_(unfolded_protein_response)