- members of E3 complexes
- yeast Der1p: multi-pass transmembrane protein that interacts with Hrd1p and Hrd3p as well as with substrates
- dispensable for degradation of many substrates
- contain a motif shared with rhomboid proteases (which recognize and cleave protein sequences within the membrane using hydrophilic residues within their TM domains); lack catalytic sites
- luminal ERAD substrates are typically more dependent on Derlins
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