Derlin (Der1p, DER1)

Function:
 * members of E3 complexes
 * yeast Der1p: multi-pass transmembrane protein that interacts with Hrd1p and Hrd3p as well as with substrates
 * dispensable for degradation of many substrates
 * contain a motif shared with rhomboid proteases (which recognize and cleave protein sequences within the membrane using hydrophilic residues within their TM domains); lack catalytic sites
 * luminal ERAD substrates are typically more dependent on Derlins


 * m