UPR (unfolded protein response)

Definition:


 * UPR orchestrates increased expression of key ERAD components
 * in metazoans, different arms of the UPR up-regulate distinct sets of ERAD components (Yoshida et al., 2003; Dev Cell; Bernasconi et al., 2008; JBC) --> cells can dynamically alter the specificity of ERAD, not just its overall activity